Nasser Nilton
Universidade Regional de Blumenau, SC, Brazil.
An Bras Dermatol. 2012 Jul-Aug;87(4):585-9. doi: 10.1590/s0365-05962012000400011.
Warts are epithelial proliferations in the skin and mucous membrane caused by various types of HPV. They can decrease spontaneously or increase in size and number according to the patient's immune status. The Propionium bacterium parvum is a strong immune stimulant and immune modulator and has important effects in the immune system and it is able to produce antibodies in the skin.
To show the efficacy of the Propionium bacterium parvum in saline solution in the treatment of skin warts.
A randomized double-blind study. Twenty patients with multiple warts were divided into two groups: one received 0,1 ml intradermal injection of placebo solution in just one of the warts and the other received 0,1 ml of saline solution of Propionium bacterium parvum, one dose a month, for 3 to 5 months.
Among the 20 patients who participated in the study, ten received the placebo and ten received the saline solution with Propionium bacterium parvum. In 9 patients treated with the Propionium bacterium parvum solution the warts disappeared without scars and in 1 patient it decreased in size. In 9 patients who received the placebo no change to the warts was observed and in 1 it decreased in size.
The immune modulator and immune stimulant Propionium bacterium parvum produced antibodies in the skin which destroyed the warts without scars, with statistically significant results (P<0,001), and cured 90 % of the patients. We suggest the use of the immune stimulant in the treatment of warts.
疣是由各种类型的人乳头瘤病毒（HPV）引起的皮肤和黏膜上皮增生。它们可根据患者的免疫状态自行消退或增大、增多。短小丙酸杆菌是一种强大的免疫刺激剂和免疫调节剂，在免疫系统中具有重要作用，且能够在皮肤中产生抗体。
展示短小丙酸杆菌生理盐水溶液治疗皮肤疣的疗效。
一项随机双盲研究。20例多发性疣患者被分为两组：一组仅在一个疣内进行0.1 ml皮内注射安慰剂溶液，另一组接受0.1 ml短小丙酸杆菌生理盐水溶液，每月一剂，共3至5个月。
参与研究的20例患者中，10例接受安慰剂，10例接受短小丙酸杆菌生理盐水溶液。接受短小丙酸杆菌溶液治疗的9例患者疣消失且无瘢痕，1例患者疣体积减小。接受安慰剂的9例患者疣无变化，1例患者疣体积减小。
免疫调节剂和免疫刺激剂短小丙酸杆菌在皮肤中产生抗体，可消除疣且无瘢痕，结果具有统计学意义（P<0.001），治愈了90%的患者。我们建议使用这种免疫刺激剂治疗疣。
