Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Neurol Sci. 2013 Apr;34(4):557-60. doi: 10.1007/s10072-012-1176-9. Epub 2012 Aug 15.
Orthostatic hypotension and non-dipping are relatively common autonomic dysfunctions in patients with Parkinson disease (PD). These abnormalities have been thought to occur independently of striatal dopaminergic depletion; however, only little preliminary information is available. In this study, we investigated the association of neurocirculatory changes with striatal dopamine transporter status in 69 patients with early PD. Seventeen patients had orthostatic hypotension and 55 patients were non-dippers. A comparison between cases with and without orthostatic hypotension was insignificant for striatal dopamine transporter uptake. These insignificances continued in a comparison of dippers and non-dippers. These results suggest that sympathetic noradrenergic dysfunctions in PD are independent of striatal dopamine transporter depletion.
直立性低血压和非杓型血压是帕金森病（PD）患者中相对常见的自主神经功能障碍。这些异常被认为与纹状体多巴胺能缺失无关；然而，仅有少量初步信息可用。在这项研究中，我们调查了 69 例早期 PD 患者的神经循环变化与纹状体多巴胺转运体状态之间的关联。17 例患者存在直立性低血压，55 例患者为非杓型血压。存在与不存在直立性低血压的病例之间的纹状体多巴胺转运体摄取无显著差异。在杓型血压和非杓型血压的比较中，这些差异仍然存在。这些结果表明，PD 中的交感神经去甲肾上腺素能功能障碍与纹状体多巴胺转运体缺失无关。
