非人灵长类动物2型糖尿病的研究与治疗

Investigation and treatment of type 2 diabetes in nonhuman primates.

作者信息

Hansen Barbara C

机构信息

Departments of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL, USA.

出版信息

Methods Mol Biol. 2012;933:177-85. doi: 10.1007/978-1-62703-068-7_11.

DOI:10.1007/978-1-62703-068-7_11

PMID:22893407

Abstract

Nonhuman primates provide the ideal animal model for discovering and examining further the mechanisms underlying human type 2 diabetes mellitus. In all aspects studied to date the nonhuman primate has been shown to develop the same disease with the same features that develop in overweight middle-aged humans. This includes the progressive development of the known complications of diabetes, all of which are extraordinarily like those identified in humans. In addition, for the development and evaluation of new therapeutic agents, the translation of findings from nonhuman primates to application in humans has been highly predictable. Both therapeutic efficacy and identification of potential adverse responses can be effectively examined in nonhuman primates due to their great similarity to humans at the molecular, biochemical, and physiological levels. This chapter provides guidance for the development and management of a colony of monkeys with naturally occurring type 2 diabetes mellitus.

摘要

非人灵长类动物为进一步发现和研究人类2型糖尿病的潜在机制提供了理想的动物模型。在迄今为止所研究的各个方面，非人灵长类动物已被证明会患上与超重中年人类相同特征的同一种疾病。这包括糖尿病已知并发症的渐进发展，所有这些都与在人类中发现的并发症非常相似。此外，对于新治疗药物的开发和评估，从非人灵长类动物的研究结果到人类应用的转化具有高度可预测性。由于它们在分子、生化和生理水平上与人类高度相似，因此可以在非人灵长类动物中有效地检验治疗效果和潜在不良反应的识别。本章为患有自然发生的2型糖尿病的猴群的饲养和管理提供指导。