Chandler F W, McClure H M, Campbell W G, Watts J C
Arch Pathol Lab Med. 1976 Mar;100(3):163-7.
Pulmonary infection with Pneumocystis carinii was detected in two aged owl monkeys (Aotus trivirgatus) and two young chimpanzees (Pan troglodytes). The clinical histories of the owl monkeys were similar and included progressive weight loss, anorexia, failure to thrive, and death. One of the owl monkeys had no concurrent disease, whereas the other had been experimentally inoculated with Treponema pallidum 44 months before death. In both chimpanzees, an underlying myeloproliferative malignant neoplasm was associated with Pneumocystis infection. Pneumocystis organisms were found in alveolar spaces and alveolar lining cells by light and electron microscopy. Pathologic features of these untreated cases and a case in a chimpanzee treated with pentamidine isethionate were similar to those described in humans. To our knowledge, this is the first report of pulmonary pneumocystosis associated with death in nonhuman primates.
在两只老年夜猴（Aotus trivirgatus）和两只幼年黑猩猩（Pan troglodytes）中检测到卡氏肺孢子虫肺部感染。夜猴的临床病史相似，包括进行性体重减轻、厌食、发育不良和死亡。其中一只夜猴没有并发疾病，而另一只在死亡前44个月曾被实验性接种梅毒螺旋体。在两只黑猩猩中，潜在的骨髓增殖性恶性肿瘤与肺孢子虫感染有关。通过光学显微镜和电子显微镜在肺泡腔和肺泡衬里细胞中发现了肺孢子虫生物体。这些未经治疗的病例以及一例用乙磺半胱氨酸治疗的黑猩猩病例的病理特征与人类描述的相似。据我们所知，这是首例与非人灵长类动物死亡相关的肺部肺孢子虫病报告。
