Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC Taiwan.
Small. 2012 Dec 7;8(23):3584-8. doi: 10.1002/smll.201201743. Epub 2012 Aug 15.
Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T(g) of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.
当施加高频磁场时，通过与包裹在 PLGA 空心微球壳中的氧化铁纳米粒子的耦合将产生热量。随着温度接近 PLGA 的玻璃化转变温度 (Tg)，聚合物链变得更加移动，从而增加 PLGA 基质的自由体积，并显著增强药物分子的扩散。
