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智能多功能中空微球，用于在细胞内溶酶体隔室内快速释放药物。

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments.

机构信息

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.

出版信息

Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8086-9. doi: 10.1002/anie.201102852. Epub 2011 Jul 12.

DOI:10.1002/anie.201102852
PMID:21751316
Abstract

Prepared to self-destruct: when poly(D, L-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO(3) entered the endocytic organelles of a live cell, the NaHCO(3) in the aqueous core reacted with protons that infiltrated from the compartment to generate CO(2) gas. The evolution of CO(2) bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin.

摘要

准备自我毁灭

当含有 NaHCO(3) 的聚（D，L-乳酸-共-乙醇酸）（PLGA）空心微球进入活细胞的内吞细胞器时，水核中的 NaHCO(3) 与从隔室渗透进来的质子反应生成 CO(2) 气体。CO(2) 气泡的产生导致 PLGA 壳形成小孔，从而迅速释放包裹的药物阿霉素。

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