MacLennan A H, Rodrigues L V, Krutli D R, Klomp A
Department of Obstetrics and Gynecology, Queen Victoria Hospital, University of Adelaide, South Australia.
Contraception. 1990 Sep;42(3):309-13. doi: 10.1016/0010-7824(90)90018-q.
One-hundred patients undergoing Falope ring or clip laparoscopic tubal ligation were given either a placebo or a 100 mg indomethacin rectal suppository one hour pre-operatively. Treatment was randomised and double-blind. Post-operative analgesic requirements and side effects were monitored. Forty-seven patients receiving indomethacin and 48 patients receiving placebo were available for analysis. Thirty-five patients in the indomethacin group required Meperidine (pethidine) analgesia (mean dose 58 mg) compared to 41 patients (mean dose 65 mg) in the placebo group. These differences were not significant. There were no significant differences in the non-narcotic analgesia given to each group, the side effects or the number requiring to stay overnight in the hospital. Analysis of the analgesic requirements of the 53 patients having clip sterilization and the 42 patients sterilized with Falope rings showed no statistical differences. This trial suggests that the immediate post-operative discomfort rates between ring and clip tubal occlusion are not different and that there is no significant benefit from the use of an indomethacin suppository pre-operatively.
一百例行法洛皮环或夹子腹腔镜输卵管结扎术的患者在术前一小时被随机给予安慰剂或100毫克吲哚美辛直肠栓剂。治疗采用随机双盲法。监测术后镇痛需求和副作用。47例接受吲哚美辛治疗的患者和48例接受安慰剂治疗的患者可供分析。吲哚美辛组35例患者需要哌替啶镇痛（平均剂量58毫克），而安慰剂组有41例患者（平均剂量65毫克）需要。这些差异不显著。两组在非麻醉性镇痛、副作用或需要住院过夜的人数方面没有显著差异。对53例行夹子绝育术的患者和42例行法洛皮环绝育术的患者的镇痛需求分析显示无统计学差异。该试验表明，法洛皮环和夹子输卵管闭塞术后即时不适发生率无差异，术前使用吲哚美辛栓剂无显著益处。
