Jimbo Keisuke, Shimizu Toshiaki
Department of Pediatrics, Juntendo University Faculty of Medicine.
Nihon Rinsho. 2012 Aug;70(8):1338-42.
In the past 10 years, enterohemorrhagic Escherichia coli (EHEC) infection in infants and children has not been decreased in Japan. Clinical manifestations may include history of diarrhea, a visibly bloody stool, fever, and abdominal tenderness those last for about 2 weeks and restore naturally. However, if the patients suffer from hemolytic uremic syndrome (HUS) that may be fatal infrequently. The major treatment for EHEC infection and HUS have been therapies for these symptons. Therefore new therapeutic agents for vero toxin (VT) have been developed, but that is still experimental. We describe the latest clinical researches and treatment strategies in this paper.
在过去10年中，日本婴幼儿肠出血性大肠杆菌（EHEC）感染率并未下降。临床表现可能包括腹泻史、肉眼可见的血便、发热和腹部压痛，这些症状持续约2周后自然恢复。然而，患者若患上溶血性尿毒症综合征（HUS），则偶尔可能致命。EHEC感染和HUS的主要治疗方法一直是针对这些症状的治疗。因此，已经开发出了针对志贺毒素（VT）的新型治疗药物，但仍处于实验阶段。我们在本文中描述了最新的临床研究和治疗策略。
