Chen Jeon-Hor, Chan Siwa, Liu Yi-Jui, Yeh Dah-Cherng, Chang Chih-Kai, Chen Li-Kuang, Pan Wei-Fan, Kuo Chih-Chen, Lin Muqing, Chang Daniel H E, Fwu Peter T, Su Min-Ying
Tu and Yuen Center for Functional Onco-Imaging of Department of Radiological Science, University of California Irvine, California 92697-5020, USA.
Med Phys. 2012 Aug;39(8):4886-95. doi: 10.1118/1.4736824.
To compare the breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from breast MRI of the same women using four different MR scanners.
The study was performed in 34 healthy Asian volunteers using two 1.5T (GE and Siemens) and two 3T (GE and Philips) MR scanners. The BV, FV, and PD were measured on nonfat-suppressed T1-weighted images using a comprehensive computer algorithm-based segmentation method. The scanner-to-scanner measurement difference, and the coefficient of variation (CV) among the four scanners were calculated. The measurement variation between two density morphological patterns presenting as the central type and the intermingled type was separately analyzed and compared.
All four scanners provided satisfactory image quality allowing for successful completion of the segmentation processes. The measured parameters between each pair of MR scanners were highly correlated, with R(2) ≥ 0.95 for BV, R(2) ≥ 0.99 for FV, and R(2) ≥ 0.97 for PD in all comparisons. The mean percent differences between each pair of scanners were 5.9%-7.8% for BV, 5.3%-6.5% for FV, 4.3%-7.3% for PD; with the overall CV of 5.8% for BV, 4.8% for FV, and 4.9% for PD. The variation of FV was smaller in the central type than in the intermingled type (p = 0.04).
The results showed that the variation of FV and PD measured from four different MR scanners is around 5%, suggesting the parameters measured using different scanners can be used for a combined analysis in a multicenter study.
比较使用四种不同磁共振成像（MRI）扫描仪对同一女性乳房MRI测量的乳房体积（BV）、纤维腺体组织体积（FV）和密度百分比（PD）。
对34名健康亚洲志愿者使用两台1.5T（通用电气和西门子）和两台3T（通用电气和飞利浦）MRI扫描仪进行研究。使用基于计算机算法的综合分割方法，在非脂肪抑制的T1加权图像上测量BV、FV和PD。计算扫描仪之间的测量差异以及四台扫描仪之间的变异系数（CV）。分别分析和比较呈现为中央型和混合型的两种密度形态模式之间的测量差异。
所有四台扫描仪均提供了令人满意的图像质量，使得分割过程能够成功完成。在所有比较中，每对MRI扫描仪之间测量的参数高度相关，BV的R(2)≥0.95，FV的R(2)≥0.99，PD的R(2)≥0.97。每对扫描仪之间的平均百分比差异BV为5.9%-7.8%，FV为5.3%-6.5%，PD为4.3%-7.3%；BV的总体CV为5.8%，FV为4.8%，PD为4.9%。中央型FV的变异小于混合型（p = 0.04）。
结果表明，使用四种不同MRI扫描仪测量的FV和PD的变异约为5%，这表明使用不同扫描仪测量的参数可用于多中心研究的联合分析。
