University of California, Irvine, Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, Irvine, California, USA.
J Biomed Opt. 2012 Jul;17(7):071311. doi: 10.1117/1.JBO.17.7.071311.
The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near infrared light propagation in thick tissues. We present theory and methods of DOI focusing on model-based techniques for quantitative, in vivo measurements of endogenous tissue absorption and scattering properties. We specifically emphasize the common conceptual framework of the scalar photon density wave for both temporal and spatial frequency-domain approaches. After presenting the history, theoretical foundation, and instrumentation related to these methods, we provide a brief review of clinical and preclinical applications from our research as well as our outlook on the future of DOI technology.
作者描述了漫射光学成像（DOI）技术的发展，特别是利用空间和时间调制来控制近红外光在厚组织中的传播。我们介绍了 DOI 聚焦的理论和方法，重点是基于模型的技术，用于对内源性组织吸收和散射特性进行定量、活体测量。我们特别强调了时间和空间频域方法中普遍存在的标量光子密度波的共同概念框架。在介绍了这些方法的历史、理论基础和仪器设备之后，我们简要回顾了我们的研究中的临床和临床前应用，以及我们对 DOI 技术未来的展望。
