Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA.
Cell Cycle. 2012 Sep 15;11(18):3358-69. doi: 10.4161/cc.21277. Epub 2012 Aug 16.
The BTB-ZF (broad-complex, tramtrack and bric-à-brac--zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.
BTB-ZF（broad-complex、tramtrack 和 bric-à-brac--zinc finger）蛋白至少由 49 个基因在小鼠和人类中编码，通常作为基因表达的序列特异性沉默子。这篇综述将重点介绍哺乳动物 BTB-ZF 蛋白的已知生理功能，包括在免疫系统发育中的重要作用。我们讨论了它们在终末分化淋巴细胞及其前体细胞中的功能、在造血恶性肿瘤中的作用以及免疫系统以外的作用。
