Section of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Med Sci Sports Exerc. 2013 Jan;45(1):109-15. doi: 10.1249/MSS.0b013e31826beae5.
Whereas greater physical activity (PA) is known to prevent cardiovascular disease (CVD), the relative importance of performing PA in sustained bouts of activity versus shorter bouts of activity on CVD risk is not known. The objective of this study was to investigate the relationship between moderate-to-vigorous PA (MVPA), measured in bouts ≥10 and <10 min, and CVD risk factors in a well-characterized community-based sample of white adults.
We conducted a cross-sectional analysis of 2109 participants in the Third Generation Cohort of the Framingham Heart Study (mean age = 47 yr, 55% women) who underwent objective assessment of PA by accelerometry over 5-7 d. Total MVPA, MVPA done in bouts ≥10 min (MVPA(10+)), and MVPA done in bouts <10 min (MVPA(<10)) were calculated. MVPA exposures were related to individual CVD risk factors, including measures of adiposity and blood lipid and glucose levels, using linear and logistic regression.
Total MVPA was significantly associated with higher HDL levels and with lower triglycerides, BMI, waist circumference, and Framingham risk score (P < 0.0001). MVPA(<10) showed similar statistically significant associations with these CVD risk factors (P < 0.001). Compliance with national guidelines (≥150 min of total MVPA) was significantly related to lower BMI, triglycerides, Framingham risk score, waist circumference, higher HDL, and a lower prevalence of obesity and impaired fasting glucose (P < 0.001 for all).
Our cross-sectional observations on a large middle-age community-based sample confirm a positive association of MVPA with a healthier CVD risk factor profile and indicate that accruing PA in bouts <10 min may favorably influence cardiometabolic risk. Additional investigations are warranted to confirm our findings.
虽然人们已知更多的身体活动（PA）可预防心血管疾病（CVD），但进行长时间持续活动与短时间多次活动对 CVD 风险的相对重要性尚不清楚。本研究的目的是调查在一个特征明确的白种人社区样本中，以 10 分钟及以上和 10 分钟以下的时间间隔衡量的中等到剧烈体力活动（MVPA）与 CVD 风险因素之间的关系。
我们对弗雷明汉心脏研究第三代队列的 2109 名参与者进行了横断面分析（平均年龄为 47 岁，55%为女性），这些参与者通过加速度计在 5-7 天内进行了 PA 的客观评估。计算了总 MVPA、持续时间≥10 分钟的 MVPA（MVPA(10+)）和持续时间<10 分钟的 MVPA（MVPA(<10)）。使用线性和逻辑回归将 MVPA 暴露与个体 CVD 风险因素（包括肥胖和血脂、血糖水平的测量）相关联。
总 MVPA 与较高的 HDL 水平和较低的甘油三酯、BMI、腰围和弗雷明汉风险评分显著相关（P<0.0001）。MVPA(<10)与这些 CVD 风险因素也存在相似的统计学显著关联（P<0.001）。符合国家指南（≥150 分钟总 MVPA）与较低的 BMI、甘油三酯、弗雷明汉风险评分、腰围、较高的 HDL 以及肥胖和空腹血糖受损的患病率较低显著相关（P<0.001）。
我们在一个大型中年社区样本中的横断面观察结果证实了 MVPA 与更健康的 CVD 风险因素谱之间存在正相关关系，并表明在 10 分钟以下的时间间隔内积累 PA 可能有利于影响心血管代谢风险。需要进一步的研究来证实我们的发现。
