University Hospital Duesseldorf, Duesseldorf, Germany.
Int J Legal Med. 2012 Nov;126(6):953-6. doi: 10.1007/s00414-012-0750-2. Epub 2012 Aug 16.
Isotretinoin is considered to be a safe and effective therapy in otherwise therapy-resistant acne. Elevated serum creatine phosphokinase values with or without muscle-related symptoms in isotretinoin-treated patients have been reported and interpreted as benign phenomena, lethal cases have not been described yet. We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.
异维 A 酸被认为是一种安全有效的治疗方法，尤其适用于其他治疗方法抵抗的痤疮。在接受异维 A 酸治疗的患者中，已经报告了血清肌酸磷酸激酶值升高，伴有或不伴有肌肉相关症状，并被解释为良性现象，但尚未描述致命病例。我们报告了一例 20 岁男性患者，因严重的全身性横纹肌溶解症与异维 A 酸治疗相关而死亡。
