Dasgupta Kingshuk, Lim Peter, Reedstorm Hannah
Department of Pediatrics/Pediatric Critical Care, Sanford School of Medicine of the University of South Dakota/Avera McKennan Children's Hospital & University Health Center, Sioux Falls, USA.
Department of Pediatric Infectious Diseases, University Hospitals (UH) Cleveland Medical Center - Rainbow Babies and Children's Hospital, Cleveland, USA.
Cureus. 2020 Oct 13;12(10):e10929. doi: 10.7759/cureus.10929.
Isotretinoin or 13-cis-retinoic acid, a derivative of vitamin A, is a highly effective therapy for severe and resistant acne. Its usage is restricted worldwide because of its teratogenic potential. The most common side effects are dermatologic, cheilitis, increased skin fragility, and susceptibility to sunburns. Rare side effects include myalgias and arthralgias. It also causes transient laboratory abnormalities such as elevated creatine kinase (CK). Very few cases of isotretinoin-induced severe muscle injury leading to rhabdomyolysis have been reported in the literature. We report a 15-year-old adolescent who developed rhabdomyolysis after a bout of vigorous exercising while on long-term isotretinoin therapy.
异维A酸或13 - 顺式维甲酸，是维生素A的衍生物，是治疗重度及难治性痤疮的高效疗法。因其有致畸潜力，其使用在全球范围内受到限制。最常见的副作用是皮肤方面的，如唇炎、皮肤脆性增加以及易晒伤。罕见的副作用包括肌痛和关节痛。它还会导致一些短暂的实验室异常，如肌酸激酶（CK）升高。文献中报道的异维A酸诱发严重肌肉损伤导致横纹肌溶解的病例极少。我们报告一名15岁青少年，在长期接受异维A酸治疗期间，一次剧烈运动后发生了横纹肌溶解。
