NZOZ "Promed", Kielce, Poland.
Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):3023-8. doi: 10.1007/s10096-012-1656-0. Epub 2012 Aug 16.
The aim of this study was an analysis of the population effects of a seven-valent pneumococcal conjugate vaccine (PCV7) on pneumonia incidence rates in the 5-year follow-up period after the introduction in 2006 of a universal PCV7 vaccination programme in the city of Kielce, Poland. Vaccinations were carried out according to a 2 + 1 schedule. The vaccination compliance rate amounted to approximately 99 %. The age groups 0-2, 30-49, 50-65 and 65+ years were analysed. The Cochran-Armitage test was used to investigate the significance of observed trends in pneumonia morbidity. The significance of deviations from a linear trend was also tested. The importance of the trend was confirmed by the Mantel test. Between 2005 and 2010, the greatest decline, 82.9 % (2005, 25.31/1,000; 2010, 4.34/1,000), in pneumonia morbidity was observed for children <2 years of age. In the 65+ years age group, this amounted to 43.5 %. Lesser declines, but still of statistical significance, were observed for the other age groups: 16.5 % in the 30-49 years group and 40.4 % in the 50-64 years group. All reductions are statistically significant and confirmed by the Mantel test. Five years after the introduction of a universal PCV7 vaccination programme in Kielce, Poland, its effectiveness in pneumonia prevention has been demonstrated in both the <2 years of age group and indirectly for other groups.
本研究旨在分析 2006 年波兰凯尔采市实施通用 7 价肺炎球菌结合疫苗（PCV7）接种计划后，5 年随访期间该疫苗对肺炎发病率的人群影响。接种按照 2+1 方案进行。疫苗接种的遵守率约为 99%。分析了 0-2 岁、30-49 岁、50-65 岁和 65+岁年龄组。采用 Cochran-Armitage 检验分析肺炎发病率的变化趋势。还检验了线性趋势偏差的显著性。Mantel 检验证实了趋势的重要性。2005 年至 2010 年间，2 岁以下儿童的肺炎发病率下降幅度最大，为 82.9%（2005 年，25.31/1000；2010 年，4.34/1000）。65 岁以上年龄组的降幅为 43.5%。其他年龄组的降幅虽小，但仍有统计学意义：30-49 岁年龄组为 16.5%，50-64 岁年龄组为 40.4%。所有降幅均有统计学意义，并通过 Mantel 检验得到证实。在波兰凯尔采市实施通用 PCV7 接种计划 5 年后，该计划在预防肺炎方面的有效性已在<2 岁年龄组得到证实，并间接在其他年龄组得到证实。
