Identification of chaperones as essential components of the tumor rejection moieties of cancers.
作者信息
Srivastava Pramod K
机构信息
Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, USA.
出版信息
Cancer Immun. 2012;12:5. Epub 2012 May 1.
Abstract
摘要
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Ovalbumin-derived precursor peptides are transferred sequentially from gp96 and calreticulin to MHC class I in the endoplasmic reticulum.卵清蛋白衍生的前体肽在粗面内质网中从 gp96 和钙网蛋白依次转移到 MHC Ⅰ类分子。
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Treg suppress CTL responses upon immunization with HSP gp96.Treg 抑制 HSP gp96 免疫后 CTL 的应答。
Eur J Immunol. 2009 Nov;39(11):3110-20. doi: 10.1002/eji.200939593.
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"It is the antigen(s), stupid" and other lessons from over a decade of vaccitherapy of human cancer.“是抗原，笨蛋”以及人类癌症十多年疫苗治疗的其他经验教训。
Semin Immunol. 2008 Oct;20(5):296-300. doi: 10.1016/j.smim.2008.07.003. Epub 2008 Aug 20.
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An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial.辅助性自体治疗性疫苗（HSPPC-96；维特司班）对比单纯观察用于肾细胞癌肾切除术后复发高危患者：一项多中心、开放标签、随机III期试验
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The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.强化规则的例外情况：逃脱降解的胞质肽的交叉启动。
Immunity. 2008 Jun;28(6):787-98. doi: 10.1016/j.immuni.2008.04.015.
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Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation.热休克蛋白90与N端延伸肽相关联，是直接和间接抗原呈递所必需的。
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Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway.热休克蛋白90α（Hsp90α）在MHC I类抗原加工途径中陪伴大的C末端延伸的蛋白水解中间体。
Immunity. 2006 May;24(5):523-34. doi: 10.1016/j.immuni.2006.03.015.
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Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells.由热休克蛋白陪伴的肽段是CD8 + T细胞交叉致敏过程中抗原的必要且充分来源。
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Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. 1982.用单克隆抗体鉴定的小鼠T淋巴瘤的肿瘤特异性抗原。1982年。
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