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人肾上腺分离细胞的皮质类固醇生成:血清素及血清素拮抗剂的作用

Corticosteroidogenesis by isolated human adrenal cells: effect of serotonin and serotonin antagonists.

作者信息

Rácz K, Wolf I, Kiss R, Lada G, Vida S, Gláz E

出版信息

Experientia. 1979 Nov 15;35(11):1532-4. doi: 10.1007/BF01962830.

DOI:10.1007/BF01962830
PMID:228968
Abstract

The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid - particularly cortisol and aldosterone - biosynthesis.

摘要

在源自库欣综合征患者的离体肾上腺细胞中,研究了血清素和抗血清素药物对肾上腺类固醇生物合成的直接影响。结果表明,血清素可增加皮质酮的生成,而血清素拮抗剂赛庚啶和麦角酰二乙胺则会抑制肾上腺类固醇——尤其是皮质醇和醛固酮——的生物合成。

相似文献

1
Corticosteroidogenesis by isolated human adrenal cells: effect of serotonin and serotonin antagonists.人肾上腺分离细胞的皮质类固醇生成:血清素及血清素拮抗剂的作用
Experientia. 1979 Nov 15;35(11):1532-4. doi: 10.1007/BF01962830.
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Acute self-suppression of corticosteroidogenesis in isolated adrenocortical cells.
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引用本文的文献

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Role of neurotransmitters and neuropeptides in the regulation of the adrenal cortex.神经递质和神经肽在肾上腺皮质调节中的作用。
Rev Endocr Metab Disord. 2001 Aug;2(3):253-67. doi: 10.1023/a:1011512415497.
2
The effect of carcinoid levels of serotonin and substance P on hemodynamics.类癌水平的血清素和P物质对血流动力学的影响。
Ann Surg. 1984 Feb;199(2):197-204. doi: 10.1097/00000658-198402000-00012.

本文引用的文献

1
A technic for the preparation of isolated rat adrenal cells.一种制备分离大鼠肾上腺细胞的技术。
Proc Soc Exp Biol Med. 1969 May;131(1):1-4. doi: 10.3181/00379727-131-33789.
2
Use of corticosteroid antibodies for the study of corticosteroid biosynthesis in vitro.使用皮质类固醇抗体进行体外皮质类固醇生物合成的研究。
J Steroid Biochem. 1975 Mar-Apr;6(3-4):383-7. doi: 10.1016/0022-4731(75)90161-2.
3
Steroidogenesis in isolated rat adrenal glomerulosa cells: response to physiological concentrations of angiotensin II and effects of potassium, serotonin and [Sar1,Ala8]-angiotensin II.
J Endocrinol. 1977 Aug;74(2):261-72. doi: 10.1677/joe.0.0740261.
4
Aldosterone diagnosis in hypertension: comparative evaluation of radioimmunoassays for urinary aldosterone and 18-OH-corticosterone.
Klin Wochenschr. 1978;56 Suppl 1:173-81. doi: 10.1007/BF01477470.
5
Serotonin regulation of ACTH secretion.促肾上腺皮质激素分泌的血清素调节。
Ann N Y Acad Sci. 1977 Oct 28;297:527-35. doi: 10.1111/j.1749-6632.1977.tb41880.x.
6
Studies on isolated rat adrenal cells. I. Continuous flow and batch incubation.大鼠肾上腺细胞分离研究。I. 连续流动与批量孵育
Acta Endocrinol (Copenh). 1975 Jan;78(1):110-21. doi: 10.1530/acta.0.0780110.