人肾上腺分离细胞的皮质类固醇生成：血清素及血清素拮抗剂的作用
Corticosteroidogenesis by isolated human adrenal cells: effect of serotonin and serotonin antagonists.
作者信息
Rácz K, Wolf I, Kiss R, Lada G, Vida S, Gláz E
出版信息
Experientia. 1979 Nov 15;35(11):1532-4. doi: 10.1007/BF01962830.
PMID:228968
Abstract
The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid - particularly cortisol and aldosterone - biosynthesis.
摘要
在源自库欣综合征患者的离体肾上腺细胞中，研究了血清素和抗血清素药物对肾上腺类固醇生物合成的直接影响。结果表明，血清素可增加皮质酮的生成，而血清素拮抗剂赛庚啶和麦角酰二乙胺则会抑制肾上腺类固醇——尤其是皮质醇和醛固酮——的生物合成。
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