Petrova T S, Bazhenov N D, Mazur V V, Mazur E S
Klin Med (Mosk). 2012;90(4):32-4.
Gustatory sensitivity threshold to table salt (GST) and extracellular fluid volume (EFV) were determined in 128 patients with arterial hypertension (mean age 54.1+-0.5 yr; 79 men) before and 3 month after antihypertensive therapy. Those with the initially high GST (sensing salt in its 0.32% solution) had AP 161+-2/97+-1 mm Hg, myocardial mass 235.1+-13.2 g and left ventricular diastolic size 4.91+-0.07 compared with 151 +- 1/93+-1, 203.5+-7.8 and 4.71+-0.05 respectively in patients with low GST. The treatment resulted in a decrease of AP and EFV by 14-19 and 12% respectively in all the patients. In those with high GST it decreased after intake of indapamide by 49% vs 24 % in the absence of therapy. In patients with initially low GST it decreased (by 37%) only after intake of diuretics. It is concluded that changes of GST reflect activation of mechanisms leading to a stable drop of AP.
在128例高血压患者（平均年龄54.1±0.5岁；79例男性）中，在抗高血压治疗前及治疗3个月后测定了对食盐的味觉敏感性阈值（GST）和细胞外液量（EFV）。初始GST较高（能感知0.32%溶液中的盐）的患者收缩压/舒张压为161±2/97±1 mmHg，心肌质量为235.1±13.2 g，左心室舒张尺寸为4.91±0.07，而GST较低的患者分别为151±1/93±1、203.5±7.8和4.71±0.05。治疗使所有患者的收缩压和EFV分别降低了14 - 19%和12%。在GST较高的患者中，服用吲达帕胺后其降低了49%，而未治疗时降低了24%。在初始GST较低的患者中，仅在服用利尿剂后其降低了（37%）。结论是，GST的变化反映了导致收缩压稳定下降的机制的激活。
