Puhlmann W H, Strüder P
Arzt für Innere Medizin, Gehrden.
Fortschr Med. 1990 Nov 30;108(34):660-2.
In a trial conducted in a physician's office, the adequacy of a single daily dose of the ACE-inhibitor captopril in the management of hypertension was investigated by 24-hour monitoring. Patients of both sexes shown by conventional blood pressure measurements to respond to captopril were included in the study. After a two-week washout period, during which no anti-hypertensive treatment was given, the patients were subjected to 24-hour blood pressure monitoring prior to and following eight weeks of treatment with a daily dose of 50 mg captopril. At the end of the treatment period the mean 24-hour systolic blood pressure decreased from 158 (SD +/- 24) mmHg to 131 (SD +/- 20) mmHg, and the mean 24-hour diastolic blood pressure from 99 (SD +/- 22) mmHg to 84 (SD +/- 14) mmHg. No side effects were observed. These results show that a single daily dose of captopril suffices to reduce blood pressure adequately over 24 hours also under outpatient conditions.
在一项于医生办公室进行的试验中，通过24小时监测研究了血管紧张素转换酶抑制剂卡托普利每日单剂量治疗高血压的有效性。研究纳入了经传统血压测量显示对卡托普利有反应的男女患者。在为期两周的洗脱期内，不给患者进行抗高血压治疗，之后在给予每日50毫克卡托普利治疗八周前后，对患者进行24小时血压监测。治疗期末，24小时平均收缩压从158（标准差±24）毫米汞柱降至131（标准差±20）毫米汞柱，24小时平均舒张压从99（标准差±22）毫米汞柱降至84（标准差±14）毫米汞柱。未观察到副作用。这些结果表明，在门诊条件下，卡托普利每日单剂量也足以在24小时内充分降低血压。
