链脲佐菌素诱导的糖尿病对大鼠药物代谢的影响。
Effects of streptozotocin-induced diabetes on drug metabolism in rats.
作者信息
Emudianughe T S, Kalderon B, Gopher A, Lapidot A
机构信息
Department of Isotope Research, Weizmann Institute of Science, Rehovot, Israel.
出版信息
Arch Int Pharmacodyn Ther. 1988 May-Jun;293:14-9.
The metabolism of salicylic acid was investigated in male normal and diabetic rats. The results showed a decrease in urinary excretion of salicylic-glucuronic acid in diabetic animals and this decrease is statistically significant (P less than or equal to 0.01), while the urinary excretion of salicyluric acid in the diabetic group was higher than in controls and statistically significant (P less than or equal to 0.001). There was no marked difference between normal and diabetic rats in total urinary excretion of salicylic acid and metabolites.
在雄性正常大鼠和糖尿病大鼠中研究了水杨酸的代谢情况。结果显示，糖尿病动物尿中水杨酸葡萄糖醛酸的排泄量减少，且这种减少具有统计学意义（P≤0.01），而糖尿病组中水杨尿酸的尿排泄量高于对照组，且具有统计学意义（P≤0.001）。正常大鼠和糖尿病大鼠在水杨酸及其代谢产物的总尿排泄量上没有显著差异。
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