i3 Research, Basking Ridge, NJ, USA.
Int J Clin Pract. 2012 Sep;66(9):883-90. doi: 10.1111/j.1742-1241.2012.02960.x.
The objective of this qualitative interview study was to assess the content validity of the Benign Prostatic Hyperplasia Impact Index (BII) in a sample of men with signs and symptoms of Benign Prostatic Obstruction believed to be caused by benign prostatic hyperplasia (BPH lower urinary tract symptoms/BPH-LUTS) using concept elicitation (CE) and cognitive interviewing (CI) methods.
Fifty men with BPH-LUTS participated in the study; 27 completed CE interviews and 23 completed cognitive interviews.
Patient's average age was 69 years with a mean duration of BPH-LUTS of 6.5 years. IPSS scores ranged from 8 to 33 (higher scores indicating greater symptom severity). Overall, the most frequent symptoms (prevalence of ≥ 75%) reported spontaneously or after further explanation were awakening from sleep, increased daytime voiding (frequency), urgent desire to void (urgency), slow stream, and feeling of incomplete bladder emptying. Symptoms primarily recognized in response to follow up probe questions with a prevalence of ≥ 40% included terminal dribble, splitting of urinary stream, intermittent stream, straining and post-micturition dribble. Especially bothersome [> 5 on the numerical rating scale (NRS) of 0-10] and frequent symptoms included urgency and awakening at night to void. Discomfort or pain while urinating and post-micturition dribble were equally bothersome though less frequent. Five BPH symptom-related impact themes were identified: coping, daily responsibilities, emotion, lifestyle and relationships, and sleep.
The BII was found to be easily understood, does capture clinically relevant BPH impacts related to urinary trouble and problems, and does capture most of the important symptom-related impacts as described by participants in this study.
本定性访谈研究的目的是使用概念发掘（CE）和认知访谈（CI）方法，评估良性前列腺增生影响指数（BII）在一组被认为由良性前列腺增生（BPH 下尿路症状/BPH-LUTS）引起的有良性前列腺增生（BPH）症状和体征的男性样本中的内容效度。
50 名 BPH-LUTS 患者参加了这项研究；27 名完成了 CE 访谈，23 名完成了认知访谈。
患者的平均年龄为 69 岁，BPH-LUTS 的平均持续时间为 6.5 年。IPSS 评分范围为 8 至 33（分数越高表示症状越严重）。总体而言，最常见的症状（发生率≥75%）是从睡眠中醒来、白天排尿次数增加（频率）、尿急（紧迫性）、排尿缓慢和感觉膀胱未完全排空。主要通过后续跟进探针问题识别出的症状（发生率≥40%）包括尿末滴沥、尿流分叉、间歇性尿流、用力和排尿后滴沥。特别令人困扰的[数字评分量表（NRS）上的> 5，范围为 0-10]和频繁的症状包括尿急和夜间醒来排尿。排尿时不适或疼痛以及排尿后滴沥同样令人困扰，但频率较低。确定了与 BPH 相关的五个症状影响主题：应对、日常责任、情绪、生活方式和人际关系以及睡眠。
BII 被发现易于理解，确实捕捉到了与排尿问题相关的临床相关 BPH 影响，并且确实捕捉到了本研究参与者描述的大多数重要的与症状相关的影响。
