Utrecht University, Department of Pharmaceutics, Department of Pharmaceutical Sciences, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.
Expert Opin Drug Deliv. 2012 Oct;9(10):1225-43. doi: 10.1517/17425247.2012.716824. Epub 2012 Aug 16.
In recent years, extensive multidisciplinary investigations have been carried out in the area of cancer nanotechnology. Gold nanoparticles (GNPs) have emerged as promising carrier for delivery of various pay-loads into their target. In view of their unique physicochemical and optical properties, GNPs have been exploited for multimodality imaging, tumor targeting, and as transporter of various therapeutics. Additionally, GNPs have been used as photothermal therapeutics against cancer.
This review will focus on recent progress in the field of gold nanomaterials in cancer therapy and diagnosis. Moreover, concern about the toxicity of gold nanomaterials is addressed.
GNPs present versatile scaffolds for efficient delivery of cancer chemotherapeutics. Tuneable chemistry of the GNPs contributes to their ever increasing use in oncology research. The promises of a functional cancer therapy using GNPs have been extensively demonstrated, although the materials are still in their infancy stage and not surfaced to meet clinical standards.
近年来，癌症纳米技术领域开展了广泛的多学科研究。金纳米粒子（GNPs）已成为将各种有效载荷递送至靶标的有前途的载体。鉴于其独特的物理化学和光学特性，GNPs 已被用于多模态成像、肿瘤靶向以及各种治疗药物的转运体。此外，GNPs 已被用作癌症的光热治疗。
本综述将重点介绍金纳米材料在癌症治疗和诊断领域的最新进展。此外，还将讨论对金纳米材料毒性的关注。
GNPs 是高效递送达癌化疗药物的多功能支架。GNPs 的可调化学性质有助于其在肿瘤学研究中的应用日益增加。使用 GNPs 进行功能性癌症治疗的前景已得到广泛证实，尽管这些材料仍处于起步阶段，尚未达到满足临床标准的水平。
