Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States.
Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States; Department of Neurosciences, Medical University of South Carolina, Charleston, SC, United States.
Adv Cancer Res. 2018;139:163-184. doi: 10.1016/bs.acr.2018.05.001. Epub 2018 May 24.
Gold nanoparticles (Au NPs) are very attractive and versatile nanoparticles since they have a remarkable capacity to absorb and scatter light, convert optical energy into heat via nonradiative electron relaxation dynamics, and surface chemistries that can be capitalized upon so that the nanoparticles act as drug carriers. Au NPs have excellent stability and biocompatibility, tailorable shapes and sizes, an easily functionalized surface, high drug-loading capacity, and low toxicity. The properties of Au NPs can be leveraged to develop more precisely targeted and effective cancer therapeutics. Au NPs have been used to target delivery of chemotherapeutic agents, complement radiation and thermal therapy, and enhance contrast for in vivo imaging of the tumor in a variety of cancer types and diseased organs.
金纳米粒子（Au NPs）是非常有吸引力和多功能的纳米粒子，因为它们具有显著的吸收和散射光的能力，通过非辐射电子弛豫动力学将光学能量转化为热能，以及可以利用的表面化学，使纳米粒子作为药物载体。Au NPs 具有极好的稳定性和生物相容性、可调节的形状和尺寸、易于功能化的表面、高载药能力和低毒性。Au NPs 的特性可用于开发更精确靶向和有效的癌症治疗方法。Au NPs 已被用于靶向递送达化疗药物，补充辐射和热疗，并增强各种癌症类型和病变器官中肿瘤的体内成像对比度。
