膳食叶酸与病例对照研究网络中的癌症风险。
Dietary folates and cancer risk in a network of case-control studies.
机构信息
Department of Epidemiology, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan.
Department of Epidemiology, Istituto di Ricerche Farmacologiche 'Mario Negri', Milan.
出版信息
Ann Oncol. 2012 Oct;23(10):2737-2742. doi: 10.1093/annonc/mds212. Epub 2012 Aug 16.
BACKGROUND
Folate deficiency leads to DNA damage and inadequate repair, caused by a decreased synthesis of thymidylate and purines. We analyzed the relationship between dietary folate intake and the risk of several cancers.
PATIENTS AND METHODS
The study is based on a network of case-control studies conducted in Italy and Switzerland in 1991-2009. The odds ratios (ORs) for dietary folate intake were estimated by multiple logistic regression models, adjusted for major identified confounding factors.
RESULTS
For a few cancer sites, we found a significant inverse relation, with ORs for an increment of 100 μg/day of dietary folate of 0.65 for oropharyngeal (1467 cases), 0.58 for esophageal (505 cases), 0.83 for colorectal (2390 cases), 0.72 for pancreatic (326 cases), 0.67 for laryngeal (851 cases) and 0.87 for breast (3034 cases) cancers. The risk estimates were below unity, although not significantly, for cancers of the endometrium (OR = 0.87, 454 cases), ovary (OR = 0.86, 1031 cases), prostate (OR = 0.91, 1468 cases) and kidney (OR = 0.88, 767 cases), and was 1.00 for stomach cancer (230 cases). No material heterogeneity was found in strata of sex, age, smoking and alcohol drinking.
CONCLUSIONS
Our data support a real inverse association of dietary folate intake with the risk of several common cancers.
背景
叶酸缺乏会导致脱氧胸苷酸和嘌呤合成减少，从而引起 DNA 损伤和修复不足。我们分析了饮食叶酸摄入量与几种癌症风险之间的关系。
患者和方法
本研究基于 1991 年至 2009 年在意大利和瑞士进行的病例对照网络研究。通过多变量逻辑回归模型估计饮食叶酸摄入量的比值比（OR），并调整了主要确定的混杂因素。
结果
对于一些癌症部位，我们发现了显著的负相关关系，饮食叶酸摄入量增加 100μg/天，口腔癌（1467 例）、食管癌（505 例）、结直肠癌（2390 例）、胰腺癌（326 例）、喉癌（851 例）和乳腺癌（3034 例）的 OR 分别为 0.65、0.58、0.83、0.72 和 0.87。尽管子宫内膜癌（OR=0.87，454 例）、卵巢癌（OR=0.86，1031 例）、前列腺癌（OR=0.91，1468 例）和肾癌（OR=0.88，767 例）的风险估计值低于 1.00，但这些癌症的风险估计值低于 1.00，而前列腺癌（OR=0.91，1468 例）和肾癌（OR=0.88，767 例）的风险估计值低于 1.00，而胃癌（OR=0.91，1468 例）的风险估计值则为 1.00（230 例）。在性别、年龄、吸烟和饮酒分层中未发现明显的异质性。
结论
我们的数据支持饮食叶酸摄入量与几种常见癌症风险之间存在真实的负相关关系。
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