Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-Universität München, Thalkirchner Strasse 36, D-80337 Munich, Germany.
Nat Rev Cancer. 2012 Sep;12(9):613-26. doi: 10.1038/nrc3318. Epub 2012 Aug 17.
In recent years, microRNAs (miRNAs) have been identified as mediators of tumour suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated miRNAs contribute to tumour suppression by controlling the expression of central components of multiple processes, including cell cycle progression, epithelial-mesenchymal transition, stemness, metabolism, cell survival and angiogenesis. The expression and activity of p53 itself is also under the control of miRNAs. Finally, genetic and epigenetic alterations identified in the p53-miRNA network indicate that these pathways are important for the initiation and progression of tumours. In the future, knowledge about the p53-miRNA network may be able to be exploited for diagnostic and therapeutic approaches in cancer prevention and treatment.
近年来，microRNAs（miRNAs）已被确定为 p53 肿瘤抑制因子发挥肿瘤抑制和应激反应的介质。p53 调节的 miRNAs 通过控制多个过程的核心组成部分的表达来促进肿瘤抑制，包括细胞周期进程、上皮-间充质转化、干性、代谢、细胞存活和血管生成。p53 自身的表达和活性也受到 miRNAs 的控制。最后，在 p53-miRNA 网络中鉴定的遗传和表观遗传改变表明，这些途径对于肿瘤的发生和进展很重要。将来，有关 p53-miRNA 网络的知识可能能够用于癌症预防和治疗中的诊断和治疗方法。
