Department of Veterinary Medicine, College of Veterinary Medicine and Stem Cell Research Therapeutic Institute, Kyungpook National University, Daegu 702-701, Republic of Korea.
Evid Based Complement Alternat Med. 2012;2012:895729. doi: 10.1155/2012/895729. Epub 2012 Jul 30.
Pistacia chinensis (Chinese pistache) is a widely grown plant in southern China where the galls extract is a common practice in folk medicine. However, extracts from this plant have never been attempted for their cardiovascular protective effects in experimental setting. Here therefore we aimed to investigate the antiplatelet activity of Pistacia chinensis methanolic extract (PCME) in ADP stimulated rat platelets in vitro. PCME (2.5-20 μg/mL) inhibited ADP-induced platelet aggregation. While PCME diminished [Ca(2+)]i, ATP, and TXA2 release in ADP-activated platelets, it enhanced cAMP production in resting platelets. Likewise, PCME inhibited fibrinogen binding to αIIbβ3 and downregulated JNK, ERK, and Akt phosphorylations. Thus, PCME contains potential antiplatelet compounds that could be deployed for their therapeutic values in cardiovascular pathology.
黄连木（黄连木）是中国南方广泛种植的植物，其虫瘿提取物在民间医学中是一种常见的做法。然而，从未有人尝试在实验环境中用这种植物提取物来保护心血管。因此，我们旨在研究黄连木甲醇提取物（PCME）在体外对 ADP 刺激的大鼠血小板的抗血小板活性。PCME（2.5-20μg/ml）抑制 ADP 诱导的血小板聚集。虽然 PCME 减少了 ADP 激活血小板中[Ca（2+）]i、ATP 和 TXA2 的释放，但它增加了静息血小板中环磷酸腺苷的产生。同样，PCME 抑制纤维蛋白原与αIIbβ3 的结合，并下调 JNK、ERK 和 Akt 的磷酸化。因此，PCME 含有潜在的抗血小板化合物，可用于心血管病理的治疗价值。
