Emerging Technologies Division, National Research Council, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
ACS Appl Mater Interfaces. 2012 Sep 26;4(9):4934-41. doi: 10.1021/am301304h. Epub 2012 Aug 27.
A microfluidic approach to preparing superparamagnetic microspheres with tunable porosity is described. In this method, droplets consisting of iron oxide nanoparticles, a functional polymer and solvent are formed in a microfluidic channel. The droplets are subsequently collected in solutions of sodium dodecyl sulfate (SDS) where the solvent is left to diffuse out of the droplet phase. By adjusting the concentration of the SDS and the polarity of the solvent of the dispersed phase, the porosity of the microparticles is controlled from non porous to porous structure. The formation of the pores is shown to depend on the rate at which solvent diffuses out of the droplet phase and the availability of SDS to adsorb at the droplet interface.
介绍了一种用于制备具有可调孔隙率的超顺磁微球的微流控方法。在该方法中，由氧化铁纳米粒子、功能聚合物和溶剂组成的液滴在微流道中形成。随后，将液滴收集在十二烷基硫酸钠（SDS）溶液中，溶剂从液滴相中扩散出来。通过调节 SDS 的浓度和分散相溶剂的极性，可以控制微球的孔隙率从无孔到多孔结构。结果表明，孔的形成取决于溶剂从液滴相扩散出来的速度以及 SDS 在液滴界面吸附的能力。
