Rico G, Smith S V, Siddiqui Y, Whyte A, Gombos D, Lee A G
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
Eye (Lond). 2017 Aug;31(8):1245-1248. doi: 10.1038/eye.2017.77. Epub 2017 May 12.
PurposeTo describe the neuro-ophthalmologic findings of cholangiocarcinoma.MethodsWe report a retrospective chart review of cholangiocarcinoma patients presenting at two tertiary care centers in the Texas Medical Center.ResultsFive patients with neuro-ophthalmologic symptoms related to cholangiocarcinoma were identified. One patient presented with diplopia due to metastasis to the left medial rectus muscle, two patients had metastasis to the occipital lobe resulting in homonymous hemianopsia, one patient had involvement of the clivus resulting in sixth nerve palsy, and one presented with a hypercoagulable state-related stroke causing a homonymous hemianopsia and visual hallucinations.ConclusionsNeuro-ophthalmic manifestations of cholangiocarcinoma depend upon both mechanism and localization. We report five cases of cholangiocarcinoma with neuro-ophthalmologic findings. To our knowledge, this is the largest such series reported in the English language ophthalmic literature.
目的
描述胆管癌的神经眼科表现。
方法
我们对德克萨斯医学中心两家三级医疗中心收治的胆管癌患者进行了回顾性病历审查。
结果
确定了5例与胆管癌相关的神经眼科症状患者。1例因转移至左内直肌出现复视，2例转移至枕叶导致同向性偏盲，1例斜坡受累导致展神经麻痹，1例因高凝状态相关中风导致同向性偏盲和视幻觉。
结论
胆管癌的神经眼科表现取决于机制和定位。我们报告了5例有神经眼科表现的胆管癌病例。据我们所知，这是英文眼科文献中报道的此类最大系列病例。
