Postgraduate Student, Department of Periodontology, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):e450-6. doi: 10.1016/j.oooo.2012.02.033. Epub 2012 Aug 15.
The aim of the present study was to evaluate the effects of β-tricalcium phosphate/carboxymethyl-chitin material (β-TCP/CM-chitin) on bone formation in rat calvarial defects.
Eighteen animals surgically received 2 calvarial defects (5 mm) bilaterally in each parietal bone. β-TCP/CM-chitin was implanted in one side of each defect, and the contralateral side of the defect was left empty as a control. The animals were humanely killed at 4, 8, and 12 weeks after surgery for histologic evaluation.
New bone formation in the β-TCP/CM-chitin group was significantly greater than that in the control group throughout the healing periods (P < .05). β-TCP/CM-chitin was remarkably resorbed 12 weeks after surgery.
These results indicate that β-TCP/CM-chitin is useful as a scaffold for bone formation.
本研究旨在评估β-磷酸三钙/羧甲基壳聚糖（β-TCP/CM-壳聚糖）材料对大鼠颅骨缺损骨形成的影响。
18 只动物双侧顶骨各接受 2 个颅骨缺损（5mm）。β-TCP/CM-壳聚糖植入一侧，另一侧作为对照不植入。术后 4、8、12 周时，对动物进行人道处死，进行组织学评估。
在整个愈合期内，β-TCP/CM-壳聚糖组的新骨形成明显大于对照组（P<.05）。术后 12 周时，β-TCP/CM-壳聚糖显著吸收。
这些结果表明，β-TCP/CM-壳聚糖可用作骨形成的支架。
