β-磷酸三钙/羧甲基壳聚糖复合支架在大鼠颅骨缺损中诱导成骨的研究。
Bone formation using β-tricalcium phosphate/carboxymethyl-chitin composite scaffold in rat calvarial defects.
机构信息
Postgraduate Student, Department of Periodontology, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):e450-6. doi: 10.1016/j.oooo.2012.02.033. Epub 2012 Aug 15.
OBJECTIVE
The aim of the present study was to evaluate the effects of β-tricalcium phosphate/carboxymethyl-chitin material (β-TCP/CM-chitin) on bone formation in rat calvarial defects.
STUDY DESIGN
Eighteen animals surgically received 2 calvarial defects (5 mm) bilaterally in each parietal bone. β-TCP/CM-chitin was implanted in one side of each defect, and the contralateral side of the defect was left empty as a control. The animals were humanely killed at 4, 8, and 12 weeks after surgery for histologic evaluation.
RESULTS
New bone formation in the β-TCP/CM-chitin group was significantly greater than that in the control group throughout the healing periods (P < .05). β-TCP/CM-chitin was remarkably resorbed 12 weeks after surgery.
CONCLUSIONS
These results indicate that β-TCP/CM-chitin is useful as a scaffold for bone formation.
目的
本研究旨在评估β-磷酸三钙/羧甲基壳聚糖（β-TCP/CM-壳聚糖）材料对大鼠颅骨缺损骨形成的影响。
研究设计
18 只动物双侧顶骨各接受 2 个颅骨缺损（5mm）。β-TCP/CM-壳聚糖植入一侧，另一侧作为对照不植入。术后 4、8、12 周时，对动物进行人道处死，进行组织学评估。
结果
在整个愈合期内，β-TCP/CM-壳聚糖组的新骨形成明显大于对照组（P<.05）。术后 12 周时，β-TCP/CM-壳聚糖显著吸收。
结论
这些结果表明，β-TCP/CM-壳聚糖可用作骨形成的支架。
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