Nauczyciel C, Drapier D
Unité de recherche universitaire 425 « Comportement et noyaux gris centraux », université de Rennes 1, service hospitalo-universitaire de Rennes, centre hospitalier Guillaume-Regnier, Rennes cedex, France.
Rev Neurol (Paris). 2012 Aug-Sep;168(8-9):655-61. doi: 10.1016/j.neurol.2012.05.006. Epub 2012 Aug 15.
Obsessive-compulsive disorder (OCD) is a chronic, often resistant neuropsychiatric disorder leading to severe social impairment. Neurophysiological theories suggest an imbalance between the frontal-striatal circuits involved in goal directed behavior. Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a therapeutic option. Various targets of stimulation have been tested based on neurophysiological theories. The first studies, stimulating the dorsolateral prefrontal cortex, did not show an efficacy but the more recent ones, stimulating the supplementary motor area or the orbitofrontal cortex, seem to be promising. Further studies with larger sample should be conducted in order to propose rTMS as a therapeutic tool for OCD.
强迫症（OCD）是一种慢性的、通常具有难治性的神经精神障碍，会导致严重的社会功能损害。神经生理学理论表明，参与目标导向行为的额叶-纹状体回路之间存在失衡。重复经颅磁刺激（rTMS）已被提议作为一种治疗选择。基于神经生理学理论，已经对各种刺激靶点进行了测试。最初刺激背外侧前额叶皮层的研究未显示出疗效，但最近刺激辅助运动区或眶额叶皮层的研究似乎很有前景。应该进行更大样本量的进一步研究，以便将rTMS作为强迫症的一种治疗工具。
