Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA.3-127, P.O. Box 75867, 1070 AW, Amsterdam, The Netherlands.
Curr Psychiatry Rep. 2011 Aug;13(4):289-94. doi: 10.1007/s11920-011-0205-3.
Obsessive-compulsive disorder (OCD) is a chronic, disabling disorder. Ten percent of patients remain treatment refractory despite several treatments. For these severe, treatment-refractory patients, repetitive transcranial magnetic stimulation (rTMS) has been suggested as a treatment option. Since 1997, in published trials, a total of 110 OCD patients have been treated with rTMS. This review aims to provide an update on rTMS treatment in patients with OCD. First, the mechanism of action is discussed, followed by the efficacy and side effects of rTMS at various brain targets, and finally implications for the future. Due to the lack of studies with comparable stimulation or treatment parameters and with reliable designs, it is difficult to draw clear conclusions. In general, rTMS appears to be effective in open-label studies; however, this has not yet been replicated in randomized, sham-controlled trials.
强迫症（OCD）是一种慢性、致残性疾病。尽管进行了多次治疗，仍有 10%的患者对治疗无反应。对于这些严重的、治疗抵抗的患者，重复经颅磁刺激（rTMS）已被提议作为一种治疗选择。自 1997 年以来，在已发表的试验中，共有 110 名 OCD 患者接受了 rTMS 治疗。本综述旨在提供关于 OCD 患者 rTMS 治疗的最新信息。首先讨论了作用机制，接着讨论了 rTMS 在不同脑靶标上的疗效和副作用，最后讨论了对未来的影响。由于缺乏具有可比刺激或治疗参数和可靠设计的研究，因此难以得出明确的结论。总的来说，rTMS 在开放标签研究中似乎有效；然而，这尚未在随机、假对照试验中得到复制。
