DNA 损伤、染色质和转录：衰老的三位一体。
DNA damage, chromatin, and transcription: the trinity of aging.
机构信息
National Cancer Institute, NIH, Bethesda, United States.
出版信息
Curr Opin Cell Biol. 2012 Dec;24(6):724-30. doi: 10.1016/j.ceb.2012.07.005. Epub 2012 Aug 17.
Abstract
Aging brings about numerous cellular defects. Amongst the most prominent are elevated levels of persistent DNA damage, changes to chromatin structure and epigenetic modifications, and alterations of global transcription programs. These are not independent events and recent work begins to shed light on the intricate interplay between these aging-related defects.
摘要
衰老会导致许多细胞缺陷。其中最突出的是持续 DNA 损伤水平升高、染色质结构和表观遗传修饰改变以及全球转录程序改变。这些并不是独立的事件，最近的研究开始揭示这些与衰老相关缺陷之间的复杂相互作用。
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