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病毒性内耳疾病的最新进展。

Recent advances in viral inner ear disorders.

作者信息

Beyea Jason A, Agrawal Sumit K, Parnes Lorne S

机构信息

Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

出版信息

Curr Opin Otolaryngol Head Neck Surg. 2012 Oct;20(5):404-8. doi: 10.1097/MOO.0b013e328357a6b3.

Abstract

PURPOSE OF REVIEW

To highlight the recent advances in the understanding of the diagnosis and management of viral inner ear disorders. Congenital sensorineural hearing loss (cSNHL), sudden sensorineural hearing loss (SSNHL), Ménière's disease, and vestibular neuritis/viral labyrinthitis are discussed.

RECENT FINDINGS

Cytomegalovirus infection during pregnancy is an under-recognized cause of hearing loss and central nervous system disease amongst the general population. Prevention of maternal infection and treatment of affected newborns with ganciclovir are promising interventions. Recent evidence in SSNHL patients has resulted in recommendations against viral serology or the use of antivirals. There appears to be an increased risk of SSNHL in patients with comorbid hypertension and diabetes. The viral hypothesis of Ménière's disease remains unproven. In patients with an acute episode of vestibular neuritis, there is presently not sufficient evidence to support the routine use of corticosteroids or antiviral medications.

SUMMARY

cSNHL remains the most clearly defined of the viral inner ear disorders. The evidence for viral involvement in SSNHL, Ménière's disease, and vestibular neuritis is indirect and equivocal. This review highlights the recent advancements in the diagnosis and management of these disorders.

摘要

综述目的

重点介绍病毒感染性内耳疾病诊断和治疗方面的最新进展。讨论先天性感音神经性听力损失(cSNHL)、突发性感音神经性听力损失(SSNHL)、梅尼埃病以及前庭神经炎/病毒性迷路炎。

最新发现

孕期巨细胞病毒感染是普通人群中听力损失和中枢神经系统疾病的一个未得到充分认识的病因。预防母体感染以及用更昔洛韦治疗受影响的新生儿是有前景的干预措施。SSNHL患者的最新证据导致不建议进行病毒血清学检查或使用抗病毒药物。合并高血压和糖尿病的患者发生SSNHL的风险似乎增加。梅尼埃病的病毒假说仍未得到证实。对于急性前庭神经炎患者,目前没有足够的证据支持常规使用皮质类固醇或抗病毒药物。

总结

cSNHL仍然是定义最明确的病毒感染性内耳疾病。病毒与SSNHL、梅尼埃病和前庭神经炎相关的证据是间接的且不明确。本综述重点介绍了这些疾病诊断和治疗方面的最新进展。

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