Zhang Hualei, Qiao Hui, Ferrari Victor A, Zhou Rong
Laboratories of Molecular Imaging, Department of Radiology, University of Pennsylvania, B6 Blockley Hall, 422 Curie Boulevard, Philadelphia, PA 19104, USA. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Curr Cardiovasc Imaging Rep. 2012 Feb 1;5(1):53-59. doi: 10.1007/s12410-011-9119-z. Epub 2011 Nov 25.
Noninvasive or minimally invasive imaging techniques are essential for developing strategies and assessing outcomes of cell-based therapies for myocardial regeneration, also referred to as cellular cardiomyoplasty. Imaging-based monitoring of cell survival is useful for selection of optimal cell type and evaluating strategies to enhance engraftment. Imaging-derived surrogate end points including global and regional contractile function, myocardial blood flow, or perfusion and bioenergetics have been used in clinical trials or in relevant large animal models to evaluate the therapeutic effect and mechanisms of action of cellular cardiomyoplasty. New techniques are emerging to assess electrical integration of donor cells with host cardiomyocytes. This review will summarize and highlight important and informative findings revealed by imaging in clinical and preclinical cellular cardiomyoplasty studies over the past 3 years.
非侵入性或微创成像技术对于制定基于细胞的心肌再生治疗策略和评估治疗效果至关重要，这种治疗也被称为细胞心肌成形术。基于成像的细胞存活监测有助于选择最佳细胞类型并评估增强植入的策略。包括整体和局部收缩功能、心肌血流、灌注和生物能量学等成像衍生的替代终点已在临床试验或相关大型动物模型中用于评估细胞心肌成形术的治疗效果和作用机制。评估供体细胞与宿主心肌细胞电整合的新技术正在不断涌现。本综述将总结并突出过去3年临床和临床前细胞心肌成形术研究中成像所揭示的重要且有价值的发现。
