Goldust Mohamad, Babae Nejad Shahla, Rezaee Elham, Raghifar Ramin
Tabriz University of Medical Sciences, Student Research Committee , Tabriz, Iran , Islamic Republic of Iran.
J Dermatolog Treat. 2013 Jan 20. doi: 10.3109/09546634.2012.723122.
Objective: Treatment of scabies is an important issue in infectious dermatology. The aim of this study was to specify whether permethrin is effective for the treatment of human scabies and to compare its effectiveness with that of 1% lindane by topical application. Methods: 220 patients with scabies with the mean age of 44 ± 12/24 attended the study. Patients were divided into two groups randomly. The first group and their family contacts received 5% permethrin cream and the other received 1% lindane lotion. Treatment was evaluated at intervals of 2 and 4 weeks. Results: Of 254 patients, 220 completed the study. 110 in the group treated with lindane and 110 in the group treated with permethrin. Permethrin provided an improvement rate of 92 (83.6%) after 2 weeks, whereas lindane was effective only in 54 (49%) of patients. After 4 weeks improvement rate was 96.3% (106 of 110) in permethrin group since it was only 69.1% (76 of 110) in lindane group. Conclusion: Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study. There were no adverse effects with either permethrin or lindane.
疥疮治疗是感染性皮肤病学中的一个重要问题。本研究的目的是明确氯菊酯对治疗人类疥疮是否有效，并通过局部应用将其有效性与1%林丹的有效性进行比较。方法：220例平均年龄为44±12/24岁的疥疮患者参与了该研究。患者被随机分为两组。第一组及其家庭接触者接受5%氯菊酯乳膏，另一组接受1%林丹洗剂。每隔2周和4周对治疗效果进行评估。结果：254例患者中，220例完成了研究。林丹治疗组110例，氯菊酯治疗组110例。氯菊酯治疗2周后的改善率为92例（83.6%），而林丹仅对54例（49%）患者有效。4周后，氯菊酯组的改善率为96.3%（110例中的106例），而林丹组仅为69.1%（110例中的76例）。结论：在本研究中，发现5%氯菊酯乳膏治疗疥疮比林丹显著更有效。氯菊酯和林丹均未产生不良反应。
