State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu 610075, Sichuan, China.
Molecules. 2012 Aug 20;17(8):9939-46. doi: 10.3390/molecules17089939.
Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.
从乌头（Aconitum carmichaelii）的侧根的乙醇提取物中分离得到了两个新的生物碱：aconicarmine（1）和 aconicaramide（5），以及五个已知化合物：fuziline（2）、neoline（3）、N-ethylhokbusine B（4）、5-羟甲基吡咯-2-甲醛（6）和oleracein E（7）。通过物理和 NMR 分析阐明了它们的结构。首次从乌头中分离出吡咯生物碱。在体外实验中，化合物 2 和 3 通过明显恢复搏动节律和增加细胞活力来对抗戊巴比妥钠诱导的心肌细胞损伤，而化合物 5 和 7 表现出适度的抗菌活性。
