Shanghai Burn Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.
Dermatology. 2012;225(1):75-80. doi: 10.1159/000341530. Epub 2012 Aug 17.
Since the three-dimensional (3-D) structure of dermal tissue has an important role in regulating cell behavior and directing the wound healing process, the characteristic of the 3-D structure of dermal tissue needs to be clarified.
To explore the different 3-D structures between normal and scar dermal tissues.
Phase-contrast microtomography with synchrotron radiation technology was applied to detect the 3-D structure of dermal tissues.
The normal dermal tissue consists of elliptical structures formed by fiber bundles interwoven in a helical manner. A regular louver-like structure was observed on the fibers. In scar tissue, the fiber bundles were arrayed in parallel, the louver-like structures were disordered.
The study demonstrates the mesoscopic difference between normal dermal tissue and scar tissue, suggests that the high level of interweaving capability of collagen is compromised/lost when dermal tissue is injured, and provides a basis for future studies.
由于皮肤组织的三维（3-D）结构在调节细胞行为和指导伤口愈合过程中起着重要作用，因此需要阐明皮肤组织的 3-D 结构特征。
探索正常和瘢痕皮肤组织之间的三维结构差异。
应用同步辐射相衬显微断层成像技术检测皮肤组织的三维结构。
正常皮肤组织由纤维束以螺旋方式交织形成的椭圆形结构组成。纤维上观察到规则的百叶窗状结构。在瘢痕组织中，纤维束平行排列，百叶窗状结构紊乱。
该研究表明正常皮肤组织和瘢痕组织之间存在介观差异，提示皮肤组织损伤时胶原的高度交织能力受损/丧失，并为未来的研究提供了依据。
