Shanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, People's Republic of China.
Mol Biol Rep. 2013 Aug;40(8):4837-41. doi: 10.1007/s11033-013-2580-9. Epub 2013 May 9.
Scar formation is the problem for clinic surgery. Recent studies showed that the scar formation was closely related to the dermal defect. Three-dimensional (3-d) structures of dermal tissues act as a template to modulate cell functions that are essential the regeneration of skin structure and function. The dermal tissue's integrity and continuity is a prerequisite for repair to take place. Loss of the dermal tissue integrity and continuity due to trauma leads to a lack of the template effect, which may be one important mechanism that hinders the recovery of cell function, resulting in scar formation. These studies give us two questions: what is the three-dimensional (3-d) structure of the dermal tissue? How do the tissues form? Up to now, it is well known that the molecular structure of collagen, the micro-structure of microfibril, however, the mesoscopic structure of dermal tissues is still unclear. Our recently rudimentary studies showed the problem might be resolved by phase-contrast micro-tomography with synchrotron radiation, which is likely to open new avenues for further investigations on wound regeneration and skin tissue engineering.
瘢痕形成是临床手术的难题。最近的研究表明，瘢痕形成与皮肤缺损密切相关。真皮组织的三维（3-d）结构作为调节细胞功能的模板，对皮肤结构和功能的再生至关重要。真皮组织的完整性和连续性是修复发生的前提。由于创伤导致真皮组织完整性和连续性丧失，会导致模板效应缺失，这可能是阻碍细胞功能恢复导致瘢痕形成的重要机制之一。这些研究给我们带来了两个问题：真皮组织的三维（3-d）结构是什么？组织是如何形成的？到目前为止，人们已经熟知胶原的分子结构、微纤维的微观结构，然而，真皮组织的介观结构仍不清楚。我们最近的初步研究表明，利用同步辐射相衬显微断层摄影术可能可以解决这个问题，这可能为创伤再生和皮肤组织工程的进一步研究开辟新的途径。
