Department of Clinical Neuroscience, Kings College Hospital and Kings College, Denmark Hill, London SE5 9RS, United Kingdom.
Muscle Nerve. 2012 Sep;46(3):351-9. doi: 10.1002/mus.23320.
The aim of this study was to describe the effect of muscle disease upon QoL and to explore the influence of disease severity, mood, and illness perception on the QoL of these patients.
Validated questionnaires assessing QoL (Individualized Neuromuscular QoL and SF-36), disease severity (Health Assessment Questionnaire), mood (Hospital Anxiety and Depression Scale) and illness perception (Illness Perception Questionnaire) were sent to adults with muscle disease.
We received 302 responses (return rate 75%). QoL was reduced, particularly for "physical" domains, but "psychological" domains were also affected. Disease severity was the main determinant for the "physical" domains of QoL, but mood and illness perception played a part. Conversely, mood and illness perception were the main determinants for the "psychological" domains of QoL.
Because mood and illness perception explain significant variance in QoL in muscle disease, there is scope for devising psychosocial interventions that may improve QoL for those with muscle disease.
本研究旨在描述肌肉疾病对生活质量的影响，并探讨疾病严重程度、情绪和疾病认知对这些患者生活质量的影响。
我们向成年肌肉疾病患者发送了经过验证的生活质量评估问卷（个体化神经肌肉生活质量问卷和 SF-36）、疾病严重程度评估问卷（健康评估问卷）、情绪评估问卷（医院焦虑抑郁量表）和疾病认知评估问卷（疾病认知问卷）。
我们收到了 302 份回复（回复率为 75%）。生活质量下降，特别是在“身体”方面，但“心理”方面也受到影响。疾病严重程度是生活质量“身体”方面的主要决定因素，但情绪和疾病认知也有一定影响。相反，情绪和疾病认知是生活质量“心理”方面的主要决定因素。
由于情绪和疾病认知解释了肌肉疾病生活质量的显著差异，因此可以设计心理社会干预措施，可能会提高肌肉疾病患者的生活质量。
