Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway.
Mult Scler. 2013 Apr;19(4):451-7. doi: 10.1177/1352458512457843. Epub 2012 Aug 20.
Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination.
To investigate the association between retinol and disease activity in multiple sclerosis (MS).
Cohort study of 88 relapsing-remitting MS patients, originally included in a randomised placebo-controlled trial of omega-3 fatty acids in MS (the OFAMS study), followed prospectively for 24 months with repeated assessments of serum-retinol and magnetic resonance imaging (MRI). All patients were initiated on interferon β-1a after month 6.
Each 1 µmol/L increase in serum-retinol reduced the odds (95% confidence interval) for new T1 gadolinium enhanced (Gd(+)) lesions by 49 (8-70)%, new T2 lesions by 42 (2-66)%, and combined unique activity (CUA) by 46 (3-68)% in simultaneous MRI scans, and 63 (25-82)% for new T1Gd(+) lesions, 49 (3-73)% for new T2 lesions and 43 (12-71)% for CUA the subsequent month. Serum-retinol also predicted new T1Gd(+) and T2 lesions six months ahead. The associations were not affected by HLA-DRB1*15, or serum levels of 25-hydroxyvitamin D, eicosapentaenoic acid or docosahexaenoic acid.
Serum retinol is inversely associated with simultaneous and subsequent MRI outcomes in RRMS.
维生素 A 具有免疫调节作用，可能调节参与髓鞘修复的基因转录。
研究视黄醇与多发性硬化症（MS）疾病活动的关系。
对 88 例复发缓解型 MS 患者进行队列研究，这些患者最初被纳入 MS 中ω-3 脂肪酸的随机安慰剂对照试验（OFAMS 研究），前瞻性随访 24 个月，重复评估血清视黄醇和磁共振成像（MRI）。所有患者在第 6 个月后开始接受干扰素β-1a 治疗。
血清视黄醇每增加 1µmol/L，新 T1 钆增强（Gd(+））病变、新 T2 病变和联合独特活动（CUA）的发生几率（95%置信区间）分别降低 49（8-70）%、42（2-66）%和 46（3-68）%，在同时进行的 MRI 扫描中，新 T1Gd(+)病变、新 T2 病变和 CUA 的发生几率分别降低 63（25-82）%、49（3-73）%和 43（12-71）%，随后一个月也是如此。血清视黄醇还可以预测 6 个月后新的 T1Gd(+)和 T2 病变。这些关联不受 HLA-DRB1*15 或血清 25-羟维生素 D、二十碳五烯酸或二十二碳六烯酸水平的影响。
血清视黄醇与 RRMS 同时和随后的 MRI 结果呈负相关。
