Rai Sachchida Nand, Singh Payal, Steinbusch Harry W M, Vamanu Emanuel, Ashraf Ghulam, Singh Mohan Prasad
Centre of Biotechnology, University of Allahabad, Prayagraj 211002, India.
Department of Zoology, MMV, Banaras Hindu University, Varanasi 221005, India.
Biomedicines. 2021 Sep 22;9(10):1284. doi: 10.3390/biomedicines9101284.
Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson's disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.
获取推荐的每日维生素摄入量对于维持人类和其他动物的体内平衡至关重要。维生素缺乏或失调会对神经元代谢产生不利影响，这可能导致神经退行性疾病。在本文中，我们讨论了基于维生素的新方法如何有助于减轻基于神经退行性变的脑部疾病（如阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化症和朊病毒病）中异常的神经元功能。维生素通过抗氧化和抗炎活性在帕金森病中发挥其治疗作用。此外，不同的水溶性和脂溶性维生素也预防了β-淀粉样蛋白和tau蛋白病变。另一方面，一些结果也表明维生素作用与预防神经退行性疾病之间没有相关性。一些维生素也表现出毒性作用。本综述讨论了维生素补充剂对神经系统疾病的有益和无效作用。本文还阐述了水溶性和脂溶性维生素详细的作用机制。兴奋效应也是确定维生素有效剂量非常有帮助的一个重要因素。我们利用PubMed、谷歌学术、科学网和Scopus对原始文章、综述文章和荟萃分析进行文献检索。
