Garduño-Ramírez María Luisa, Clares Beatriz, Domínguez-Villegas Valeri, Peraire Concepción, Ruiz María Adolfina, García María Luisa, Calpena Ana C
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, México.
Nat Prod Commun. 2012 Jul;7(7):821-3.
The objective of the present study was to investigate the transdermal permeation of cacalol (1) and a mixture of cacalone (2) and 6-epi-cacalone (3) in comparison with diclofenac acid (4) delivered from the same characterized nanoemulsion using Franz diffusion cells (formulae I, II and III). Results show that de Kp, J, Q24, PI and P2 were higher for the acid diclofenac nanoemulsion than for the natural products nanoemulsions. As for the differences between the formulations I and II, with the natural products, Q24, the quantity extracted from skin and P2 were higher in the mixture of 2 and 3 nanoemulsion compared with the corresponding nanoemulsion of 1. In conclusion, the low permeability of the natural products nanoemulsions in comparison with that of diclofenac acid has the potential for development for drugs with local and systemic applications, respectively.
本研究的目的是使用Franz扩散池（配方I、II和III），研究卡考洛尔（1）以及卡考酮（2）与6-表卡考酮（3）的混合物的透皮渗透情况，并与从相同特性纳米乳剂中释放的双氯芬酸（4）进行比较。结果表明，双氯芬酸纳米乳剂的Kp、J、Q24、PI和P2高于天然产物纳米乳剂。至于配方I和II之间的差异，对于天然产物，与相应的1纳米乳剂相比，2和3纳米乳剂混合物的Q24（从皮肤中提取的量）和P2更高。总之，与双氯芬酸相比，天然产物纳米乳剂的低渗透性分别具有开发局部和全身应用药物的潜力。
