Bristol-Myers Squibb Company , PO Box 4000, Princeton, New Jersey 08543, United States.
ACS Comb Sci. 2012 Sep 10;14(9):520-6. doi: 10.1021/co300075g. Epub 2012 Aug 27.
The use of standardized lean manufacturing principles to improve drug discovery productivity is often thought to be at odds with fostering innovation. This manuscript describes how selective implementation of a lean optimized process, in this case centralized purification for medicinal chemistry, can improve operational productivity and increase scientist time available for innovation. A description of the centralized purification process is provided along with both operational and impact (productivity) metrics, which indicate lower cost, higher output, and presumably more free time for innovation as a result of the process changes described.
将标准化精益制造原则用于提高药物发现的生产力通常被认为与培养创新精神相冲突。本文描述了如何选择性地实施精益优化流程，在此情况下为药物化学实施集中纯化，即可提高运营生产力并增加科学家用于创新的时间。本文提供了集中纯化流程的描述以及运营和影响（生产力）指标，这些指标表明，由于所描述的流程变更，成本降低、产量提高，并且可能为创新留出更多自由时间。
