Discovery Chemistry & Research Technologies, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46158, USA.
Drug Discov Today. 2013 Sep;18(17-18):795-802. doi: 10.1016/j.drudis.2013.03.001. Epub 2013 Mar 21.
This article describes our experiences in creating a fully integrated, globally accessible, automated chemical synthesis laboratory. The goal of the project was to establish a fully integrated automated synthesis solution that was initially focused on minimizing the burden of repetitive, routine, rules-based operations that characterize more established chemistry workflows. The architecture was crafted to allow for the expansion of synthetic capabilities while also providing for a flexible interface that permits the synthesis objective to be introduced and manipulated as needed under the judicious direction of a remote user in real-time. This innovative central synthesis suite is herein described along with some case studies to illustrate the impact such a system is having in expanding drug discovery capabilities.
本文介绍了我们创建一个完全集成、全球可访问、自动化的化学合成实验室的经验。该项目的目标是建立一个完全集成的自动化合成解决方案，最初专注于最大限度地减少重复性、常规性、基于规则的操作负担，这些操作是更成熟的化学工作流程的特征。该架构的设计允许扩展合成能力，同时提供一个灵活的接口，允许在远程用户的明智指导下实时按需引入和操作合成目标。本文介绍了这个创新的中央合成套件，并提供了一些案例研究来说明这样的系统在扩展药物发现能力方面所产生的影响。
