Environmental NMR Centre, Department of Chemistry, University of Toronto, Toronto, Canada.
Environ Sci Technol. 2012 Nov 6;46(21):11488-96. doi: 10.1021/es302154w. Epub 2012 Aug 30.
Nuclear magnetic resonance (NMR) is arguably the most powerful and versatile tool in modern science. It has the capability to solve complex structures and interactions in situ even in complex heterogeneous multiphase samples such as soil, plants, and tissues. NMR has vast potential in environmental research and can provide insight into a diverse range of environmental processes at the molecular level be it identifying the binding site in human blood for a specific contaminant or the compositional dynamics of soil with climate change. Modern NMR-based metabonomics is elucidating contaminant toxicity and toxic mode of action rapidly and at sub lethal concentrations. Combined modern NMR approaches provide a powerful framework to better understand carbon cycling and sustainable agriculture, as well as contaminant fate, bioavailability, toxicity, sequestration, and remediation.
核磁共振(NMR)可以说是现代科学中最强大、用途最广泛的工具。它具有原位解决复杂结构和相互作用的能力,即使在复杂的多相异质样品中,如土壤、植物和组织。NMR 在环境研究中有巨大的潜力,可以在分子水平上深入了解各种环境过程,无论是确定人类血液中特定污染物的结合位点,还是气候变化下土壤的组成动态。基于现代 NMR 的代谢组学可以快速阐明污染物的毒性和毒性作用模式,而且只需亚致死浓度即可完成。结合现代 NMR 方法为更好地理解碳循环和可持续农业以及污染物的命运、生物利用度、毒性、固定和修复提供了一个强大的框架。