Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Biomacromolecules. 2012 Sep 10;13(9):2881-9. doi: 10.1021/bm300897j. Epub 2012 Aug 29.
Biodegradable poly(ester amide)s have recently been used as biomaterials due to their desirable chemical and biological characteristics as well as their mechanical properties, which are amendable for material processing. In this study, electroactive tetraaniline (TA) grafted poly(ester amide)s were successfully synthesized and characterized. The poly(ester amide)s-graft-tetraaniline copolymers (PEA-g-TA) exhibited good electroactivity, mechanical properties, and biodegradability. The biocompatibility of the PEA-g-TA copolymers in vitro was systematically studied, which demonstrated that they were nontoxic and led to favorable adhesion and proliferation of mouse preosteoblastic MC3T3-E1 cells. Moreover, the PEA-g-TA copolymers stimulated by pulsed electrical signal could serve to promote the differentiation of MC3T3-E1 cells compared with TCPs. Hence, the biodegradable and electroactive PEA-g-TA copolymers possessed the properties in favor of the long-time potential application in vivo (electrical stimulation directly to the desired area) as bone repair scaffold materials in tissue engineering.
可生物降解的聚（酯酰胺）由于其理想的化学和生物学特性以及机械性能，适用于材料加工，最近已被用作生物材料。在这项研究中，成功合成并表征了电活性四苯胺（TA）接枝聚（酯酰胺）。聚（酯酰胺）接枝四苯胺共聚物（PEA-g-TA）表现出良好的电活性、机械性能和可生物降解性。体外研究了 PEA-g-TA 共聚物的生物相容性，结果表明它们无毒性，并且有利于小鼠前成骨细胞 MC3T3-E1 细胞的黏附和增殖。此外，与 TCPs 相比，经脉冲电信号刺激的 PEA-g-TA 共聚物可促进 MC3T3-E1 细胞的分化。因此，可生物降解和电活性的 PEA-g-TA 共聚物具有有利于体内长期潜在应用（直接对所需区域进行电刺激）的特性，可作为组织工程中骨修复支架材料。
