Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, PO Box 57, 00014 University of Helsinki, Helsinki, Finland.
Vet J. 2013 Apr;196(1):52-6. doi: 10.1016/j.tvjl.2012.07.023. Epub 2012 Aug 19.
Idiopathic pulmonary fibrosis (IPF) is characterised by an abnormal accumulation of collagen type III in the pulmonary interstitium. Procollagen type III amino terminal propeptide (PIIINP) is used as a marker of collagen type III synthesis. In this study, the concentrations of PIIINP were investigated in dogs with IPF (n=15), dogs with chronic bronchitis (CB, n=19), dogs with eosinophilic bronchopneumopathy (EBP, n=13) and healthy dogs (n=25). PIIINP concentrations in serum and bronchoalveolar lavage fluid (BALF) were analysed by radioimmunoassay. Serum PIIINP values did not differ between groups, indicating that serum PIIINP is not useful in evaluating respiratory diseases in dogs. BALF PIIINP was significantly elevated in dogs with IPF compared with healthy dogs (P=0.002) and dogs with CB (P<0.001). BALF PIIINP was significantly higher in dogs with EBP than in dogs with CB (P=0.003) or healthy dogs (P=0.022). There were no differences in BALF PIIINP concentrations between dogs with IPF and dogs with EBP or between dogs with CB and healthy dogs. These results indicate that IPF is associated with elevated BALF PIIINP concentrations. BALF PIIINP concentrations also are elevated in EBP, possibly due to secondary fibrotic changes.
特发性肺纤维化（IPF）的特征是肺间质中 III 型胶原的异常积聚。III 型前胶原氨基末端前肽（PIIINP）被用作 III 型胶原合成的标志物。在这项研究中，研究了特发性肺纤维化（n=15）、慢性支气管炎（CB，n=19）、嗜酸性支气管肺炎（EBP，n=13）和健康犬（n=25）犬的 PIIINP 浓度。通过放射免疫测定法分析血清和支气管肺泡灌洗液（BALF）中的 PIIINP 浓度。血清 PIIINP 值在各组之间没有差异，表明血清 PIIINP 对评估犬的呼吸疾病没有帮助。与健康犬（P=0.002）和慢性支气管炎犬（P<0.001）相比，特发性肺纤维化犬的 BALF PIIINP 显著升高。与慢性支气管炎犬（P=0.003）或健康犬（P=0.022）相比，EBP 犬的 BALF PIIINP 显著升高。特发性肺纤维化犬和 EBP 犬之间或慢性支气管炎犬和健康犬之间的 BALF PIIINP 浓度没有差异。这些结果表明，IPF 与 BALF PIIINP 浓度升高有关。EBP 中也存在 BALF PIIINP 浓度升高，可能是由于继发性纤维化改变。
