State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Cytokine Growth Factor Rev. 2013 Feb;24(1):83-9. doi: 10.1016/j.cytogfr.2012.07.004. Epub 2012 Aug 19.
Recent achievements in the biology and the function of adipose tissue have regarded white adipose tissue (WAT) as an important endocrine and secretory organ. Releasing a series of multiple-function mediators, WAT is involved in a wide spectrum of diseases, including not only cardiovascular and metabolic complications, such as atherosclerosis and type 2 diabetes, but also inflammatory- and immune-related disorders, such as rheumatoid arthritis (RA) and osteoarthritis (OA). A large number of these mediators, called adipokines, such as tumor necrosis factor alpha (TNF-α), leptin, adiponectin, resistin, chemerin, interleukin-6 (IL-6), visfatin, and so on have been identified and studied widely. Important advances related to these proteins shed new insights into the pathophysiological mechanisms of many complicated diseases, although details of which remain unclear. Adiponectin, one of the most widely investigated adipokine, has been shown to possess both anti- and pro-inflammatory effects. RA is a chronic systemic inflammatory-related autoimmune disease. Accumulated evidence has demonstrated that cytokines and adipokines play an important role in the pathogenesis of RA. In this review, we have summarized the most recent advances in adiponectin research in the context of RA, focusing primarily on its effect on RA-related cells, its regulation on pro-inflammatory cytokines, as well as its validation as a biomarker for RA.
近年来，脂肪组织的生物学和功能研究取得了重大进展，人们开始将白色脂肪组织（WAT）视为重要的内分泌和分泌器官。WAT 释放一系列多功能介质，参与多种疾病，不仅包括心血管和代谢并发症，如动脉粥样硬化和 2 型糖尿病，还包括炎症和免疫相关疾病，如类风湿关节炎（RA）和骨关节炎（OA）。大量这些被称为脂肪因子的介质，如肿瘤坏死因子-α（TNF-α）、瘦素、脂联素、抵抗素、趋化素、白细胞介素-6（IL-6）、内脏脂肪素等，已经被广泛识别和研究。这些蛋白的重要进展为许多复杂疾病的病理生理机制提供了新的见解，尽管其中的细节仍不清楚。脂联素是研究最广泛的脂肪因子之一，它具有抗炎和促炎作用。RA 是一种慢性系统性炎症相关自身免疫性疾病。越来越多的证据表明，细胞因子和脂肪因子在 RA 的发病机制中起重要作用。在这篇综述中，我们总结了 RA 背景下脂联素研究的最新进展，重点介绍了它对 RA 相关细胞的作用、对促炎细胞因子的调节，以及作为 RA 生物标志物的验证。
