NEIRID Lab (NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases), SERGAS, Santiago University Clinical Hospital, Institute of Medical Research (IDIS), Santiago de Compostela, Spain.
Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):97-102. doi: 10.1111/bcpt.12109. Epub 2013 Jul 26.
Inflammation is a complex mechanism of cell/tissue responses to injuries triggered by multiple causes, including trauma, pathogens or autoimmune abnormal responses. In the last years, a novel line of thought is emerging by giving a more holistic vision of chronic arthropathies through a recently identified group of molecules, called adipokines. Actually, most of these recently identified factors, produced prevalently by white adipose tissue but also by cells of the joints (chondrocytes and synovial fibroblasts) and immune cells, play a significant role in chronic inflammation. Adipokines dysregulation has emerged as a common characteristic of chronic inflammation in rheumatic diseases in particular when obesity or, more precisely, adipose tissue dysfunction is associated with common rheumatic diseases, such as osteoarthritis and rheumatoid arthritis. In this MiniReview, we discuss the role of adipokines in osteoarthritis and rheumatoid arthritis providing an updated overview of their pathophysiological role and potential use as therapeutic targets.
炎症是细胞/组织对多种原因（包括创伤、病原体或自身免疫异常反应）引起的损伤的复杂反应机制。在过去的几年中，通过最近发现的一组称为脂肪因子的分子，为慢性关节炎提供了更全面的视角，出现了一种新的思路。实际上，这些最近发现的大多数因子主要由白色脂肪组织产生，但也由关节细胞（软骨细胞和滑膜成纤维细胞）和免疫细胞产生，在慢性炎症中发挥重要作用。脂肪因子失调已成为风湿性疾病中慢性炎症的共同特征，尤其是当肥胖或更确切地说，脂肪组织功能障碍与常见的风湿性疾病（如骨关节炎和类风湿关节炎）相关时。在这篇迷你综述中，我们讨论了脂肪因子在骨关节炎和类风湿关节炎中的作用，提供了其病理生理学作用的最新概述，并探讨了将其作为治疗靶点的潜力。
