Reimann-Berg N, Murua Escobar H, Nolte I
Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover, Bünteweg 9, 30559 Hannover, Germany.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2012;40(4):267-70.
For human tumours there are many reports documenting the correlation between chromosome aberrations and tumour entities. Due to the complex canine karyotypic pattern (78 chromosomes), cytogenetic studies of tumours of the dog are rare. However, the reports in the literature show, that canine chromosome 13 (CFA13) is predominantly involved in chromosomal changes. Interestingly, CFA 13 shows high homology to regions on the human chromosomes 4 (HSA 4) and 8 (HSA 8), which harbour the proto-oncogenes c-KIT and c-MYC . Both of these genes are involved in the development and progression of some human and canine tumour diseases.
关于人类肿瘤，有许多报告记录了染色体畸变与肿瘤实体之间的相关性。由于犬类复杂的核型模式（78条染色体），对犬类肿瘤的细胞遗传学研究很少。然而，文献报道显示，犬类13号染色体（CFA13）主要参与染色体变化。有趣的是，CFA 13与人类4号染色体（HSA 4）和8号染色体（HSA 8）上的区域具有高度同源性，这些区域含有原癌基因c-KIT和c-MYC。这两个基因都参与了一些人类和犬类肿瘤疾病的发生和发展。
